IL-1α and colorectal cancer pathogenesis: enthralling candidate for anti-cancer therapy

KJ Cheng, EHM Mohammed, TL Khong… - Critical reviews in …, 2021 - Elsevier
… subsequent studies, the group has developed recombinant … Open label phase II study (NCT02090101)
evaluated the … in the phase III study of Bermekimab versus placebo (each with …

[HTML][HTML] Lung cancer and oncolytic virotherapy——enemy's enemy

Z Li, Z Feiyue, L Gaofeng, L Haifeng - Translational Oncology, 2023 - Elsevier
… of lung cancer, the induction of antitumor immunity from immune cells … administration will
be hindered by antiviral immunity. Some … of intraoperative direct intratumoral injection of HF10 …

Clinical application of oncolytic viruses: a systematic review

M Cook, A Chauhan - International journal of molecular sciences, 2020 - mdpi.com
… One such example, in the activation antiviral CD8 T cells by … an OV equipped with proteins
to enhance its anti-tumor activity. … In a study of 15 patients with colorectal cancer, IV infusion of …

[HTML][HTML] Colorectal cancer immunotherapy: options and strategies

NA Johdi, NF Sukor - Frontiers in immunology, 2020 - frontiersin.org
… About 66 and 61% of stage II and III colon and rectal patients … inimical effects on antiviral
and antitumor immunity (112). … between CEA-CAR-T cells in addition to recombinant human …

Oncolytic viruses: A new immunotherapeutic approach for breast cancer treatment?

JM Cejalvo, C Falato, L Villanueva, P Tolosa… - Cancer Treatment …, 2022 - Elsevier
… system from inhibitory signals and restore the anti-tumorantiviral response pathways to
which the HSV-1 protein … with metastatic TNBC or colorectal cancer with liver metastasis have …

Harnessing cytokines and chemokines for cancer therapy

DJ Propper, FR Balkwill - Nature reviews Clinical oncology, 2022 - nature.com
… In addition to potent antiviral activities in the frontline of … to evaluate the anticancer activity
of this cytokine 21 . High-dose … the treatment of chemorefractory metastatic colorectal cancer (…

Combinatorial approaches for cancer treatment using oncolytic viruses: projecting the perspectives through clinical trials outcomes

A Malogolovkin, N Gasanov, A Egorov, M Weener… - Viruses, 2021 - mdpi.com
… of selective anti-tumor activity of recombinant adenoviruses … with avelumab in patients with
colorectal cancer [171]. The … potentiate anti-tumor immune response by retargeting antiviral

Strategies for advanced oncolytic virotherapy: current technology innovations and clinical approaches

Q Ji, Y Wu, A Albers, M Fang, X Qian - Pharmaceutics, 2022 - mdpi.com
… barriers, and antiviral host immunity during its delivery [10]. … has shown enhanced antitumor
activity [32]. Recent published data … phase II studies for patients with colorectal cancer, breast …

Combining repurposed drugs to treat colorectal cancer

D Duarte, N Vale - Drug Discovery Today, 2022 - Elsevier
… evidence that antiviral drugs can be potential candidates for CRC treatment, … the antitumor
activity of this drug in cancer cells. Currently, a Phase II clinical trial in patients with metastatic